GOLD group B includes patients with high symptom severity and low exacerbation risk. GOLD group A includes patients with low symptom severity and low exacerbation risk. The cornerstones of treatment are bronchodilator drugs of different classes including beta agonists and muscarinic antagonists ( Montuschi and Ciabattoni, 2015).Ĭurrently the Global initiative for COPD (GOLD) promotes the “ABCD” assessment of COPD patients based on symptoms severity (assessed by questionnaire) and exacerbation risk (low risk consisting in no more than one moderate – severe exacerbation during the past year).
Combo inhalers lama laba series#
COPD is a disabling disease with huge impact on normal daily activities and limiting quality of life, the disease abruptly worsen due to exacerbations inducing a step down of health conditions, following which the recovery of breath function and activities is gradually slower and more difficult leading to disability and death ( Global initiative for chronic obstructive Lung disease, 2018).įollowing this series of reasons there is a great impulse in the development of drugs able to improve symptoms, quality of life, reduce exacerbations, hospitalizations and the frequency of death of patients with COPD. COPD is associated to dyspnea, cough, and sputum with lung hyperinflation. The purpose of this review is a complete criticism of pharmacological and clinical aspects related to the use of LAMA/LABA single inhalers for the maintenance treatment of stable COPD, with particular mention to the most debated topics and future prospects in the field.Ĭhronic obstructive pulmonary disease (COPD) is believed to be the third leading cause of death worldwide by 2020 ( WHO, 2008).Ĭhronic obstructive pulmonary diseases is a common disease characterized by respiratory symptoms and progressive airflow obstruction due to alveolar and bronchial abnormalities and inflammation caused by exposition to noxious substances ( Global initiative for chronic obstructive Lung disease, 2018). Many LAMA/LABA fixed dose combinations have been licensed in different countries and the clinical use of these drugs stimulated the performance of many clinical trials. Currently the Global initiative for COPD suggests the use of long acting beta agonists (LABAs) and long acting muscarinic antagonists (LAMAs) in combination for the majority of COPD patients, thus great interest is associated with the developing of LAMA/LABA fixed combination in the maintenance treatment of stable COPD. The cornerstones of treatment are bronchodilator drugs of two different classes: beta agonists and muscarinic antagonists. Great efforts were spent in the development of drugs able to improve symptoms, quality of life, reduce exacerbations, hospitalizations and the frequency of death of patients with COPD.
4Department of Medical and Surgical Sciences, Section of Respiratory Diseases, University “Magna Græcia” of Catanzaro, Catanzaro, Italy.3Department of Medicine, Spedali Civili di Brescia, Brescia, Italy.2Respiratory Unit, Sant’Andrea Hospital, Vercelli, Italy.1Respiratory Medicine, Department of Translational Medicine, University of Eastern Piedmont, Vercelli, Italy.(accessed 7 October 2015).Mario Malerba 1,2*, Valentina Foci 1,2, Filippo Patrucco 1,2, Patrizia Pochetti 1,2, Matteo Nardin 3, Corrado Pelaia 4 and Alessandro Radaeli 5 Indacaterol with glycopyrronium (Ultibro Breezhaler) for chronic obstructive pulmonary disease. July 2015 PBAC Outcomes \u2013 Positive Recommendations, 2015. Australian Government Department of Health.Respimat PI.pdf (accessed 7 October 2015). Product Information \u2013 Spiolto Respimat 2015.
Product Information \u2013 Brimica Genuair. Public Summary Document \u2013 tiotropium bromide and olodaterol hydrochloride. Public Summary Document \u2013 Aclidinium bromide and eformoterol fumarate dihydrate.
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